ABSTRACT
To determine the frequency of raised C-reactive protein in patients with Helicobacter pylori infection. Design: Cross sectional descriptive study. Setting: Department of Medicine at Liaquat University Hospital [tertiary care teaching hospitals]. April 2012 to September 2012. All patients above 12 years of age, of either gender with history of nausea, vomiting, recurrent abdominal pain, dyspepsia or abdominal discomfort, heartburn, bloating and halitosis through casualty outdoor department [COD] or admitted in medical unit were evaluated and enrolled in the study. For the detection of Helicobacter pylori the 3 cc venous blood sample of relevant'patients was taken in a disposable syringe. After detecting the H. pylori infection, the H. pylori individuals were further evaluated for serum C-reactive protein by taking 3cc venous blood sample in a disposable syringe and sent to laboratory for analysis. The patients with raised CRP were also evaluated for their lipid profile to detect dyslipidemia. The data was collected on predesigned proforma and then entered, saved and analyzed in SPSS version 10.00. During six month study period total 92 patients with Helicobacter pylori infection were recruited and studied for serum C-reactive protein. The mean age +/- SD for overall population was 43.22 +/- 8.31, whereas the mean age +/- SD for male and female population was 41.24 +/- 7.94 and 44.76 +/- 9.42 respectively. The raised CRP was detected in 61[66%] patients [p=0.02]. The mean value +/- SD of raised CRP in male and female population was 6.30 +/- 2.86 and 7.82 +/- 3.21 respectively. Of 61 [66%] patients with raised CRP the dyslipidemia was identified in 45[74%] patients [p=0.03]. Out of 45, the raised triglycerides was observed in 08[18%] patients, low HDL in 10[22%] patients, raised LDL in 13[29%], raised cholesterol in 07[16%] whereas 07[16%] patients had mix dyslipidemia. The raised CRP was identified in patients with Helicobacter pylori infection, the dyslipidemia was observed in raised CRP population
ABSTRACT
To determine the frequency of co/super infection of hepatitis D in patients with hepatitis B related liver disorders. Descriptive study. The hepatitis Centre Ghulam Mohammad Mahar Medical College Hospitals Sukkur and Khairpur, from January 2009 to December 2009. All patient registered for HBV associated infections were selected. Blood was drawn from 200 patients who fulfilled the inclusion criteria. Those with an incomplete test profile were excluded. All clinical conditions were investigated through liver function tests, coagulation profile, abdominal ultrasonography, upper gastrointestinal endoscopy and liver biopsy. Liver cirrhosis and hepatocellular carcinoma [HCC] were diagnosed either on the basis of histology, or on a combination of radiological, endoscopic and laboratory data. Hepatitis B virus DNA was extracted from serum by real time PCR. Descriptive statistics were used for frequency and mean determination. The 129 patients finally selected for statistical analysis included 108 [84%] males and 21 [16%] females. The ages ranged from 6-68 years [mean=31.5 +/- 12.39 years]. There were 70 [54.2%] patients of non-cirrhotic, chronic hepatitis [CLD], 38 [29.4%] carriers, 12 [9.3%] cirrhotic and 9 [6.9%] hepatocellular carcinoma [HCC] patients. Among the 129 patients, 45 [34.9%] were positive for double infection with HDV. These included 35 CLD cases, 7 cirrhotic and 3 carriers. The frequency of co/super infection of hepatitis D was found to be highest in HBV cirrhosis patients compared to patients having chronic liver disease [non-cirrhotics] and carriers